Vaughan williams arrhythmias
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Antiarrhythmic drugs – an updated classification after 50 years
Together they have now published a comprehensive modern classification, based upon the original version, in the leading journal ‘Circulation’.
Findings over the past 5 decades from studies of different molecular drug targets, their mechanisms of action, and consequent clinical effects have led to the need to revise the classification.
Vaughan williams arrhythmias
The modernised Oxford classification augments Vaughan Williams’s original framework covering the actions of sodium, potassium and calcium ions and the effects on these of the nervous system (Class I-IV). Novel categories now relate to altered heart rates (Class 0), mechanical stretch (Class V); intercellular electrical communication (Class IV) and longer term structural change (Class VII).
The scheme then draws attention to multiple drug targets and actions and possible adverse, even pro-arrhythmic, effects.
This clarified classification of both the actions and therapeutic app